Utilizing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions consist of:
Our group reports bacterial cell division and is aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our key fascination lies in cell division, chromatin construction, and spatial Manage.
, Groningen scientists existing the results of their efforts to create labs a lot more sustainable and provide strategies for other labs.
I am able to barely think about how I, being a geneticist, would be capable to understand basic physics, let alone contend at the highest. How did you go about this?
That is a aspiration of mine and we established to operate using a mouth watering dose of naivety. This really is something which will most likely yield stunning brings about the for a longer time expression, but that doesn't matter. You should not only want to operate within the issues of tomorrow, but also within the issues of the day soon after tomorrow.’
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you may make this kind of synthetic mobile, would you be one particular step nearer to God, or would the function of God have diminished to some degree once again?
He also uncovered time to write down quite a few publications, send out Nearly forty thousand tweets and direct A prosperous analysis team at Delft University of Technological innovation. ‘It doesn’t feel like operate’, he suggests. ‘I’m just terribly curious.’
Imagine if, as opposed to using typical leading-down silicon electronics, transistors can be developed from The underside up making use of one natural molecules given that the switching factors? This concept, which became The idea of these days’s subject of molecular electronics, initial emerged from the 1970s.
Quite cool, but that wasn’t actually cees dekker where by my interest lay. I wished to pioneer And that i experienced the feeling that was not doable, because the most intriguing elementary insights experienced already been uncovered. But my area had formulated lots of thrilling new equipment to evaluate unique molecules. I decided which i planned to utilize this to biology, to look at it from a physical perspective.’
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Nanoscientist Cees Dekker is definitely an amiable and flamboyant man who seems Substantially more youthful compared to 62 decades he essentially is – trendy glasses, psychedelic shirt, partaking smile – but not one to squander time. He normally takes his time, but no more than vital.
2008, first observation of protein-coated DNA translocation through nanopores; settled the origin on the electrophoretic power on DNA in nanopores; identified a substantial velocity improve of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sound in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes